3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → HCID 51030793, compound

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(8-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (46 mg, 83%). 1H NMR (400 MHz, DMSO-d6): δ 7.64 (dd, J=2 and 8 Hz, 1H), 7.50-7.32 (m, 9H), 7.14-7.11 (m, 2H), 3.98 (s, 3H), 2.40-2.32 (m, 2H), 2.11-2.03 (m, 2H), 2.03-1.94 (m, 1H), 1.69-1.60 (m, 1H). LCMS (Method F): RT=8.94 min, [M+H]+=398.

Provenance & Evidence