3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-amino-cyclobutyl)-phenyl]-4-oxo-2-phenyl-4H-chromene-7-carboxylic acid amide

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(7-carbamoyl-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a cream solid (26 mg, 70%). 1H NMR (400 MHz, DMSO-d6): δ 8.30-8.26 (br s, 1H), 8.21 (d, J=2 Hz, 1H), 8.17 (d, J=8 Hz, 1H), 7.98 (dd, J=2 and 8 Hz, 1H), 7.74-7.71 (br s, 1H), 7.47-7.33 (m, 7H), 7.19-7.15 (m, 2H), 2.44-2.36 (m, 2H), 2.19-2.11 (m, 2H), 2.07-1.96 (m, 1H), 1.72-1.62 (m, 1H). LCMS (Method F): RT=8.99 min, [M+H]+=434.

Provenance & Evidence