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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1037201Generated: October 30, 2026

6-Bromo-3-iodo-2-phenyl-chromen-4-one → {1-[4-(6-Bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/1037201

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Bromo-3-iodo-2-phenyl-chromen-4-oneHCID 11582699—
Reactant{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl esterHCID 67067635—
Product{1-[4-(6-Bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl esterHCID 6706770974%

Reaction Steps

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 6-bromo-3-iodo-2-phenyl-chromen-4-one was reacted to give the title compound as a pale yellow foam (303 mg, 74%). LCMS (Method A) RT=5.02 min, [M+H]+=546/548.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08546376B2
Source datasetuspto-grants-2013_10
ORD IDord-74cc10f2e01747f787ccb7ff2705171a
Source noteuspto-grants-2013_10