3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-6-(4-methyl-piperazin-1-yl)-2-phenyl-chromen-4-one

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, (1-{4-[6-(4-methyl-piperazin-1-yl)-4-oxo-2-phenyl-4H-chromen-3-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester was reacted to give the title compound as a yellow solid (12 mg, 96%). 1H NMR (400 MHz, DMSO-d6): as 7.63-7.56 (m, 2H), 7.41-7.29 (m, 8H), 7.13-7.09 (m, 2H), 3.25-3.20 (m, 4H), 2.52-2.47 (m, 4H), 2.41-2.32 (m, 2H), 2.24 (s, 3H), 2.12-2.04 (m, 2H), 2.04-1.94 (m, 1H), 1.69-1.60 (m, 1H). LCMS (Method F): RT=6.39 min, [M+H]+=466.

Provenance & Evidence