3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-4-oxo-2-phenyl-4H-chromene-6-carbonitrile

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(6-cyano-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a yellow solid (33 mg, 94%). 1H NMR (400 MHz, DMSO-d6): δ 8.51 (d, J=2 Hz, 1H), 8.27 (dd, J=2 and 8 Hz, 1H), 7.95 (d, J=8 Hz, 1H), 7.46-7.33 (m, 7H), 7.18-7.14 (m, 2H), 2.44-2.36 (m, 2H), 2.20-2.12 (m, 2H), 2.07-1.97 (m, 1H), 1.73-1.63 (m, 1H). LCMS (Method F): RT=8.47 min, [M+H]+=393.

Provenance & Evidence