3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → HCID 51030883, compound

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Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(6,7-difluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (67 mg, 92%). 1H NMR (400 MHz, DMSO-d6): δ 8.08-7.99 (m, 2H), 7.43-7.32 (m, 7H), 7.16-7.13 (m, 2H), 2.43-2.35 (m, 2H), 2.20-2.11 (m, 2H), 2.07-1.96 (m, 1H), 1.72-1.61 (m, 1H). LCMS (Method E): RT=3.75 min, [M+H]+=404.

Provenance & Evidence