3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → HCID 51030884, compound

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(4-oxo-2-phenyl-7-trifluoromethoxy-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (54 mg, 86%). 1H NMR (400 MHz, CDCl3): δ 8.30 (d, J=8 Hz, 1H), 7.41-7.33 (m, 6H), 7.30-7.25 (m, 3H), 7.19-7.16 (m, 2H), 2.61-2.52 (m, 2H), 2.33-2.24 (m, 2H), 2.16-2.06 (m, 1H), 1.81-1.71 (m, 1H). LCMS (Method E): RT=4.15 min, [M+H]+=452.

Provenance & Evidence