{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → (1-[4-(4-oxo-2-phenyl-6-trifluoromethoxy-4H-chromen-3-yl)-phenyl]-cyclobutyl)-carbamic acid tert-butyl ester

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Reaction Steps

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 3-iodo-2-phenyl-6-trifluoromethoxy-chromen-4-one was reacted to give the title compound as a pale yellow oil (90 mg, 100%). LCMS (Method B): RT=5.07 min, [M+Na]+=574.

Provenance & Evidence