3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-6-methoxy-4-oxo-2-phenyl-4H-chromene-7-carbonitrile

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(7-cyano-6-methoxy-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a pale yellow solid (23 mg, 71%). 1H NMR (400 MHz, DMSO-d6): δ 8.41 (s, 1H), 7.65 (s, 1H), 7.43-7.32 (m, 7H), 7.16-7.12 (m, 2H), 4.02 (s, 3H), 2.42-2.35 (m, 2H), 2.17-2.09 (m, 2H), 2.06-1.96 (m, 1H), 1.72-1.62 (m, 1H). LCMS (Method E): RT=3.67 min, [M+H]+=423.

Provenance & Evidence