3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-7-(2-methoxy-ethyl)-2-phenyl-7H-pyrano[2,3-c]pyridine-4,8-dione

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, (1-{4-[7-(2-methoxy-ethyl)-4,8-dioxo-2-phenyl-7,8-dihydro-4H-pyrano[2,3-c]pyridin-3-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester was reacted to give the title compound as an off-white solid (48 mg, 72%). 1H NMR (400 MHz, DMSO-d6): δ 7.64 (d, J=7 Hz, 1H), 7.42-7.32 (m, 7H), 7.16-7.12 (m, 2H), 6.67 (d, J=7 Hz, 1H), 4.22 (t, J=5 Hz, 2H), 3.65 (t, J=5 Hz, 2H), 3.26 (s, 3H), 2.42-2.35 (m, 2H), 2.18-2.10 (m, 2H), 2.06-1.96 (m, 2H). LCMS (Method E): RT=2.93 min, [M+H]+=443.

Provenance & Evidence