HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol → 1-[4-Methoxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-yl]-3-phenyl-prop-2-yn-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol | HCID 67067672 | — |
| Reactant | 4-Methoxy-1-(2-trimethylsilanyl-ethoxymethyl)-indazole-5-carbaldehyde | HCID 86671021 | — |
| Product | 1-[4-Methoxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-5-yl]-3-phenyl-prop-2-yn-1-ol | HCID 67067769 | 98% |
Reaction Steps
Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 4-methoxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazole-5-carbaldehyde was reacted to give the title compound as a colourless oil (100 mg, 98%). LCMS (Method B): RT=4.84 min, [M+Na]+=431.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546376B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-84dba038184240c09e02b5a886e1bffb |
| Source note | uspto-grants-2013_10 |