HCID 11710014, compound → HCID 67067852, compound

HRID 1037240Notes

Reaction equation

HRID 1037240 reaction equation
[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24](F)[CH:25]=4)[O:20][C:19]=3[C:30]3[CH:35]=C[CH:33]=[CH:32][CH:31]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].IC1C(=O)C2C(OC=1C1C=CC=CC=1)=[N:42]C=CC=2>>[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:19](=[O:20])[C:30]4[C:35]([O:28][C:27]=3[C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:42][CH:33]=[CH:32][CH:31]=4)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 11710014HCID 11710014, compoundHCID 67067635{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Product 1

HCID 67067852HCID 67067852, compoundYield 66%

Procedure

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 3-iodo-2-phenyl-pyrano[2,3-b]pyridin-4-one was reacted to give the title compound (46.7 mg, 66%) as a colourless gum. LCMS (Method A): RT=4.65 min, [M+Na]+=491.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-d128e917d2cb4101a7b2af8da6110bb0
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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