HRID1037262

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(F)cc4c3=O)cc2)CCC1

HCID67067635

未命名化合物

结构：O=c1c(I)c(-c2ccccc2)oc2c(=O)n(CCO)ccc12

HCID86671034

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4c(=O)n(CCO)ccc4c3=O)cc2)CCC1

HCID86671035

未命名化合物

收率 96%

PROCEDURE

实验过程

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 7-(2-hydroxy-ethyl)-3-iodo-2-phenyl-7H-pyrano[2,3-c]pyridine-4,8-dione was reacted to give the title compound (56 mg, 96%) as a colourless solid. LCMS (Method A): RT=4.41 min, [M+H]+=529.

WORKUP

后处理

customwas reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2ec20058b4c3408d9becd8d43322f3d4
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546376B2
来源说明: uspto-grants-2013_10

反应 SMILES

[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15](C3C(=O)C4C(=CC=C(F)C=4)OC=3C3C=CC=CC=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[OH:37][CH2:38][CH2:39][N:40]1[CH:45]=[CH:44][C:43]2[C:46](=[O:57])[C:47](I)=[C:48]([C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)[O:49][C:42]=2[C:41]1=[O:58]>>[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:13]=[CH:14][C:15]([C:47]3[C:46](=[O:57])[C:43]4[CH:44]=[CH:45][N:40]([CH2:39][CH2:38][OH:37])[C:41](=[O:58])[C:42]=4[O:49][C:48]=3[C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)=[CH:16][CH:17]=2)[CH2:9][CH2:10][CH2:11]1)([CH3:4])([CH3:2])[CH3:3]