Trifluoroacetic acid → HCID 178507116, compound

Participants

Reaction Steps

To a solution, containing a mixture of (1-{-4-[6-oxo-8-phenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1,6-dihydro-chromeno[7,8-d]imidazol-7-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester and (1-{4-[6-oxo-8-phenyl-3-(2-trimethylsilanyl-ethoxymethyl)-3,6-dihydro-chromeno[7,8-d]imidazol-7-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester (11 mg, 0.017 mmol), in DCM (1.0 mL) was added TFA (0.25 mL). The reaction mixture was stirred at RT for 18 h. After this time the reaction mixture was concentrated in vacuo. The resultant residue was triturated with DCM (×2) and dried in vacuo to furnish the title compound (7.4 mg, 84%). LCMS (Method E): RT=2.76 min, [M+]+=408. 1H NMR (400 MHz, DMSO-d6): 8.69 (s, 1H), 8.67 (br s, 1H), 8.12 (d, J=8.6 Hz, 1H), 7.89 (d, J=8.7 Hz, 1H), 7.71-7.61 (m, 5H), 7.59-7.51 (m, 4H), 2.84-2.75 (m, 2H), 2.74-2.64 (m, 2H), 2.40-2.28 (m, 1H), 2.07-1.95 (m, 1H).

Provenance & Evidence