HRID1037270

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67067676

未命名化合物

结构：CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4ccccc4c3=O)cc2)CCC1

HCID67067804

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4cc(N)ccc4c3=O)cc2)CCC1

HCID67067858

未命名化合物

收率 19%

PROCEDURE

实验过程

Following the procedure used for {1-[4-(4-oxo-2-phenyl-4H-1-benzopyran-3-yl)phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 7-amino-3-bromo-2-phenyl-1-benzopyran-4-one (28.4 mg, 0.09 mmol) was reacted to give the title compound as a yellow solid (6.3 mg, 19%). 1H-NMR (400 MHz, CDCl3) δ 8.05 (d, 1H), 7.64 (d, 2H), 7.50 (d, 2H), 7.45 (d, 2H), 7.35 (dd, 1H), 7.31 (dd, 2H), 6.82 (d, 1H), 6.74 (s, 1H), 5.28 (bs, 1H), 4.11 (bs, 2H), 2.62-2.65 (m, 4H), 2.15-2.19 (m, 1H), 1.90-1.97 (m, 1H) 1.33 (bs, 9H).

WORKUP

后处理

customwas reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3ffdafc446224883987985de4b088e93
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546376B2
来源说明: uspto-grants-2013_10

反应 SMILES

[C:1]([O:5][C:6](=[O:35])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:23](=[O:24])[C:22]4[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=4[O:20][C:19]=3[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[NH2:36]C1C=CC2C(=O)C(Br)=C(C3C=CC=CC=3)OC=2C=1>>[C:1]([O:5][C:6](=[O:35])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:23](=[O:24])[C:22]4[CH:25]=[CH:26][C:27]([NH2:36])=[CH:28][C:21]=4[O:20][C:19]=3[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[CH:14][CH:13]=2)[CH2:9][CH2:10][CH2:11]1)([CH3:4])([CH3:2])[CH3:3]