3-Bromo-2-methoxybenzaldehyde → 1-(3-Bromo-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

HRID 1037277Notes

Reaction equation

HRID 1037277 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:8]([OH:17])[C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1.[Br:20]C1C(OC)=C(C=CC=1)C=O>>[Br:20][C:4]1[C:5]([O:18][CH3:19])=[C:6]([CH:8]([OH:17])[C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:2][CH:3]=1

Participants

3

Reactant 2

HCID 110638083-Bromo-2-methoxybenzaldehydeHCID 670676721-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

Product 1

HCID 670677511-(3-Bromo-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-olYield 92%

Procedure

Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 3-bromo-2-methoxy-benzaldehyde was reacted to give the title compound as an oil (3.70 g, 92%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-bdb3613286034e479d8a9a554643f29a
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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