{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → {1-[4-(8-Bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Participants

Reaction Steps

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 8-bromo-3-iodo-2-phenyl-chromen-4-one was reacted to give the title compound (73 mg, 67%). 1H NMR (400 MHz, CDCl3): δ 8.24 (dd, J=7.9 and 1.6 Hz, 1H), 7.94 (dd, J=7.7 and 1.5 Hz, 1H), 7.50 (d, J=7.0 Hz, 2H), 7.39 (d, J=8.2 Hz, 2H), 7.36-7.19 (m, 6H), 5.06 (s, 1H), 2.60-2.47 (m, 4H), 2.14-2.01 (m, 1H), 1.91-1.77 (m, 1H), 1.37 (bs, 9H).

Provenance & Evidence