3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-8-bromo-2-phenyl-chromen-4-one

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(8-bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (25 mg, 86%). 1H NMR (400 MHz, CDCl3): δ 8.20 (dd, J=7.9 and 1.5 Hz, 1H), 7.91 (dd, J=7.6 and 1.5 Hz, 1H), 7.50-7.45 (m, 2H), 7.38-7.16 (m, 8H), 2.59-2.49 (m, 2H), 2.23-1.97 (m, 3H), 1.80-1.68 (m, 1H). LCMS (Method E): RT=3.91 min, [M+H]+=446/448.

Provenance & Evidence