3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-2-phenyl-8-pyridin-3-yl-chromen-4-one

Beteiligte Stoffe

Reaktionsschritte

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(4-oxo-2-phenyl-8-pyridin-3-yl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (4 mg, 11%). 1H NMR (400 MHz, DMSO-d6): δ 8.90 (d, J=2.1 Hz, 1H), 8.59 (dd, J=4.8 and 1.6 Hz, 1H), 8.17-8.12 (m, 2H), 7.91 (dd, J=7.5 and 1.8 Hz, 1H), 7.60 (t, J=8.0 Hz, 1H), 7.52-7.48 (m, 1H), 7.36 (d, J=8.6 Hz, 2H), 7.31-7.20 (m, 5H), 7.13 (d, J=8.4 Hz, 2H), 4.05 (d, J=3.8 Hz, 2H), 2.41-2.32 (m, 2H), 2.17-2.08 (m, 2H), 2.03-1.91 (m, 1H), 1.69-1.57 (m, 1H). LCMS (Method E): RT=3.06 min, [M+H]+=445.

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