3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-7-methyl-2-phenyl-7H-pyrano[2,3-e]indazol-4-one

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(7-methyl-4-oxo-2-phenyl-4,7-dihydro-pyrano[2,3-e]indazol-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (28 mg, 84%). 1H NMR (400 MHz, DMSO-d6): δ 8.51 (d, J=1.0 Hz, 1H), 8.02 (d, J=8.8 Hz, 1H), 7.76 (dd, J=1.0 and 8.8 Hz, 1H), 7.52-7.48 (m, 2H), 7.45-7.34 (m, 5H), 7.20-7.16 (m, 2H), 4.17 (s, 3H), 2.45-2.36 (m, 2H), 2.20-2.11 (m, 2H), 2.07-1.96 (m, 1H), 1.73-1.61 (m, 1H). LCMS (Method E): RT=3.33 min, [M+H]+=422.

Provenance & Evidence