3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(1-Amino-cyclobutyl)-phenyl]-8-methyl-2-phenyl-8H-pyrano[2,3-e]indazol-4-one

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, {1-[4-(8-methyl-4-oxo-2-phenyl-4,8-dihydro-pyrano[2,3-e]indazol-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (15 mg, 89%). 1H NMR (400 MHz, DMSO-d6): δ 8.96 (s, 1H), 7.82 (d, J=9.4 Hz, 1H), 7.62 (d, J=9.4 Hz, 1H), 7.49-7.40 (m, 5H), 7.39-7.33 (m, 2H), 7.25-7.21 (m, 2H), 4.23 (s, 3H), 2.51-2.42 (m, 2H), 2.37-2.28 (m, 2H), 2.13-2.03 (m, 1H), 1.77-1.64 (m, 1H). LCMS (Method E): RT=3.13 min, [M+H]+=422.

Provenance & Evidence