反应详情

To a stirred solution of 7-hydroxymethyl-8-methoxy-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one (1.23 g, 3.78 mmol) in DCM (100 mL) was added manganese dioxide (3.30 g, 37.8 mmol). After 16 hours, the reaction mixture was filtered through Celite®. The filtrate was evaporated to dryness to afford the title compound (1.15 g, 94%) as a pale yellow solid. LCMS (Method A): RT=4.52 min, [M+Na]+=346.

1. filtrationthe reaction mixture was filtered through Celite®
2. customThe filtrate was evaporated to dryness