3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → 3-[4-(3-Amino-oxetan-3-yl)-phenyl]-8-bromo-2-phenyl-chromen-4-one

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, 2-methyl-propane-2-sulfinic acid {3-[4-(8-bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-oxetan-3-yl}-amide was reacted to give the title compound as a white solid (16 mg, 34%). 1H NMR (400 MHz, DMSO-d6): δ 8.18 (dd, J=7.8 and 1.6 Hz, 1H), 8.11 (dd, J=8.2 and 1.9 Hz, 1H), 7.54 (d, J=8.7 Hz, 2H), 7.50-7.34 (m, 6H), 7.23 (d, J=8.5, 2H), 4.71 (d, J=6.1 Hz, 2H), 4.67 (d, J=6.1 Hz, 2H), 3.32 (s, 2H). LCMS (Method E): RT=3.67 min, [M+H]+=448/450.

Provenance & Evidence