HRID1037332

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cn1ncc2ccc3c(=O)c(I)c(-c4ccccc4)oc3c21

HCID67067782

未命名化合物

结构：CC(C)(C)S(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4c(ccn5c(=O)n(COCC[Si](C)(C)C)nc45)c3=O)cn2)CCC1

HCID86671051

未命名化合物

PRODUCTS

生成物

结构：Cn1ncc2ccc3c(=O)c(-c4ccc(C5(NS(=O)C(C)(C)C)CCC5)nc4)c(-c4ccccc4)oc3c21

HCID67067841

未命名化合物

收率 81%

PROCEDURE

实验过程

Following the procedure used to prepare 2-methyl-propane-2-sulfinic acid (1-{5-[3,6-dioxo-8-phenyl-2-(2-trimethylsilanyl-ethoxymethyl)-2,6-dihydro-3H-9-oxa-1,2,3a-triaza-cyclopenta[a]naphthalen-7-yl]-pyridin-2-yl}-cyclobutyl)-amide, 7-iodo-1-methyl-8-phenyl-1H-9-oxa-1,2-diaza-cyclopenta[a]naphthalen-6-one was reacted to give the title compound (34 mg, 81%) as a pale orange gum. LCMS (Method H): RT=3.41 min, [M+H]+=527.

WORKUP

后处理

customwas reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3de558fe2bc247fa99fd3a746e05c1a7
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546376B2
来源说明: uspto-grants-2013_10

反应 SMILES

O=C1N2C=CC3C(=O)C([C:21]4[CH:22]=[CH:23][C:24]([C:27]5([NH:31][S:32]([C:34]([CH3:37])([CH3:36])[CH3:35])=[O:33])[CH2:30][CH2:29][CH2:28]5)=[N:25][CH:26]=4)=C(C4C=CC=CC=4)OC=3C2=NN1COCC[Si](C)(C)C.I[C:48]1[C:49](=[O:68])[C:50]2[C:55]([O:56][C:57]=1[C:58]1[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=1)=[C:54]1[N:64]([CH3:67])[N:65]=[CH:66][C:53]1=[CH:52][CH:51]=2>>[CH3:67][N:64]1[C:54]2=[C:55]3[C:50](=[CH:51][CH:52]=[C:53]2[CH:66]=[N:65]1)[C:49](=[O:68])[C:48]([C:21]1[CH:22]=[CH:23][C:24]([C:27]2([NH:31][S:32]([C:34]([CH3:37])([CH3:36])[CH3:35])=[O:33])[CH2:30][CH2:29][CH2:28]2)=[N:25][CH:26]=1)=[C:57]([C:58]1[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=1)[O:56]3