1,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → HCID 67067748, compound

Participants

Role	Name	HCID	Charge
Reactant	1,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole	HCID 42647313	—
Reactant	(1-{4-[4-oxo-2-phenyl-7-(2H-pyrazol-3-yl)-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester	HCID 67067641	—
Reactant	{1-[4-(8-Bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester	HCID 67067700	—
Product	HCID 67067748	HCID 67067748	78%

Reaction Steps

Following the procedure of (1-{4-[4-oxo-2-phenyl-7-(2H-pyrazol-3-yl)-4H-chromen-3-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester, {1-[4-(8-bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted with 1,5-dimethyl-1H-pyrazole-4-boronic acid pinacol ester to give the title compound (40 mg, 78%). LCMS (Method G): RT=4.12 min, [M+H]+=562.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08546376B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-f01723335cd04896b861bbc6cc2e92ed
Source note	uspto-grants-2013_10