3-[4-(1-Amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one → HCID 178507111, compound

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Reaction Steps

Following the procedure of 3-[4-(1-amino-cyclobutyl)-phenyl]-6-fluoro-2-phenyl-chromen-4-one, (1-{4-[4-oxo-2-phenyl-8-(3-trifluoromethyl-1H-pyrazol-4-yl)-4H-chromen-3-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (8 mg, 28%). 1H NMR (400 MHz, CDCl3): δ 8.31 (s, 1H), 8.11 (dd, J=8.1 and 1.8 Hz, 1H), 7.74 (dd, J=7.4 and 1.6 Hz, 1H), 7.54 (t, J=7.9 Hz, 1H), 7.36-7.27 (m, 3H), 7.26-7.18 (m, 4H), 7.08 (d, J=8.4 Hz, 2H), 3.27 (bs, 3H), 2.36-2.26 (m, 2H), 2.08-1.87 (m, 3H), 1.65-1.53 (m, 1H). LCMS (Method E): RT=3.41 min, [M+H]+=502.

Provenance & Evidence