HRID1037342

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID231360

Piperazin-2-one

C4H8N2O

HCID67067700

未命名化合物

HCID67067829

未命名化合物

PRODUCTS

产物

HCID67067777

未命名化合物

收率 64%

PROCEDURE

实验过程

Following the procedure of {1-[4-(8-morpholin-4-yl-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, {1-[4-(8-bromo-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted with 2-oxopiperazine to give the title compound as a white solid (35 mg, 64%). LCMS (Method G): RT=3.45 min, [M+H]+=566.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-0e54e1d35cf64f9a84cbc48f4b6c1a69
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08546376B2
来源说明: uspto-grants-2013_10

反应SMILES

[C:1]([O:5][C:6](=[O:41])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:27](=[O:28])[C:26]4[C:21](=[C:22]([N:29]5[CH2:34][CH2:33][O:32][CH2:31][CH2:30]5)[CH:23]=[CH:24][CH:25]=4)[O:20][C:19]=3[C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].C(OC(=O)[NH:48]C1(C2C=CC(C3C(=O)C4C(=C(Br)C=CC=4)OC=3C3C=CC=CC=3)=CC=2)CCC1)(C)(C)C.O=C1CNCCN1>>[C:1]([O:5][C:6](=[O:41])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:27](=[O:28])[C:26]4[C:21](=[C:22]([N:29]5[CH2:30][CH2:31][NH:48][C:33](=[O:32])[CH2:34]5)[CH:23]=[CH:24][CH:25]=4)[O:20][C:19]=3[C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)=[CH:14][CH:13]=2)[CH2:9][CH2:10][CH2:11]1)([CH3:4])([CH3:2])[CH3:3]