HRID1037360

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(F)cc4c3=O)cc2)CCC1

HCID67067635

未命名化合物

结构：COc1c([N+](=O)[O-])ccc2c(=O)c(I)c(-c3ccccc3)oc12

HCID67067884

未命名化合物

PRODUCTS

生成物

结构：COc1c([N+](=O)[O-])ccc2c(=O)c(-c3ccc(C4(NC(=O)OC(C)(C)C)CCC4)cc3)c(-c3ccccc3)oc12

HCID67067940

未命名化合物

收率 72%

PROCEDURE

实验过程

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 3-iodo-8-methoxy-7-nitro-2-phenyl-chromen-4-one was reacted to give the title compound as a yellow solid (390 mg, 72%). LCMS (Method G): RT=4.47 min, [M+H]+=543.

WORKUP

后处理

customwas reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-45199dbfb7ad4b2292a3b47cc0e2b7d4
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546376B2
来源说明: uspto-grants-2013_10

反应 SMILES

[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15](C3C(=O)C4C(=CC=C(F)C=4)OC=3C3C=CC=CC=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].I[C:38]1[C:47](=[O:48])[C:46]2[C:41](=[C:42]([O:52][CH3:53])[C:43]([N+:49]([O-:51])=[O:50])=[CH:44][CH:45]=2)[O:40][C:39]=1[C:54]1[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=1>>[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:13]=[CH:14][C:15]([C:38]3[C:47](=[O:48])[C:46]4[C:41](=[C:42]([O:52][CH3:53])[C:43]([N+:49]([O-:51])=[O:50])=[CH:44][CH:45]=4)[O:40][C:39]=3[C:54]3[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=3)=[CH:16][CH:17]=2)[CH2:9][CH2:10][CH2:11]1)([CH3:4])([CH3:2])[CH3:3]