3-[4-(1-Amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one → 7-[4-(1-Amino-cyclobutyl)-phenyl]-8-phenyl-1,3-dihydro-chromeno[7,8-d]imidazole-2,6-dione

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one, {1-[4-(2,6-dioxo-8-phenyl-1,2,3,6-tetrahydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a yellow solid (41 mg, 75%). 1H NMR (400 MHz, DMSO-d6): δ 7.71 (d, J=8.3 Hz, 1H), 7.63 (s, 1H), 7.53-7.49 (m, 2H), 7.44-7.38 (m, 3H), 7.35-7.30 (m, 2H), 7.22-7.19 (m, 2H), 7.14 (d, J=8.3 Hz, 1H), 7.01 (s, 1H), 2.50-2.43 (m, 2H), 2.32-2.22 (m, 2H), 2.12-2.01, (m, 1H), 1.78-1.68 (m, 1H). LCMS (Method E): RT=2.63 min, [M+H]+=424.

Provenance & Evidence