3-[4-(1-Amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one → HCID 178432083, compound

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one, {1-[4-(2-methyl-6-oxo-8-phenyl-1,6-dihydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a beige solid (20 mg, 71%). 1H NMR (400 MHz, DMSO-d6): δ 7.85 (d, J=8.9 Hz, 1H), 7.57 (d, J=8.9 Hz, 1H), 7.50-7.45 (m, 2H), 7.44-7.34 (m, 5H), 7.17-7.13 (m, 2H), 2.59 (s, 3H), 2.40-2.32 (m, 2H), 2.11-2.02 (m, 2H), 2.02-1.93 (m, 1H), 1.70-1.60 (m, 1H). LCMS (Method E): RT=2.62 min, [M+H]+=422.

Provenance & Evidence