3-[4-(1-Amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one → 7-[4-(1-Amino-cyclobutyl)-phenyl]-1,2-dimethyl-8-phenyl-1H-chromeno[7,8-d]imidazol-6-one

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one, {1-[4-(1,2-dimethyl-6-oxo-8-phenyl-1,6-dihydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (26 mg, 80%). 1H NMR (400 MHz, DMSO-d6): δ 7.84 (d, J=8.4 Hz, 1H), 7.61 (d, J=8.4 Hz, 1H), 7.52-7.49 (m, 2H), 7.44-7.34 (m, 5H), 7.16-7.13 (m, 2H), 4.09 (s, 3H), 2.61 (s, 3H), 2.41-2.33 (m, 2H), 2.12-2.03 (m, 2H), 2.03-1.93 (m, 1H), 1.70-1.61 (m, 1H). LCMS (Method E): RT=2.71 min, [M+H]+=436.

Provenance & Evidence