HuagongsheHuagongshe Chemistry Print Report · For research reference only
{1-[4-(2,6-Dioxo-8-phenyl-1,2,3,6-tetrahydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → 7-Iodo-8-phenyl-3H-chromeno[7,8-d]oxazole-2,6-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {1-[4-(2,6-Dioxo-8-phenyl-1,2,3,6-tetrahydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester | HCID 67067863 | — |
| Reactant | 7-Amino-8-hydroxy-3-iodo-2-phenyl-chromen-4-one | HCID 67067919 | — |
| Product | 7-Iodo-8-phenyl-3H-chromeno[7,8-d]oxazole-2,6-dione | HCID 67067819 | 100% |
Reaction Steps
Following the procedure used to {1-[4-(2,6-dioxo-8-phenyl-1,2,3,6-tetrahydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 7-amino-8-hydroxy-3-iodo-2-phenyl-chromen-4-one was reacted to give the title compound as a yellow solid (105 mg, 100%). LCMS (Method G): RT=3.27, [M+H]+=406.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546376B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-76c6c2f8e389484cbc5eef06a297cb7a |
| Source note | uspto-grants-2013_10 |