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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1037372Generated: October 28, 2026

{1-[4-(2,6-Dioxo-8-phenyl-1,2,3,6-tetrahydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → 7-Iodo-8-phenyl-3H-chromeno[7,8-d]oxazole-2,6-dione

https://huagongshe.com/reaction/1037372

Reaction equation

Participants

RoleNameHCIDCharge
Reactant{1-[4-(2,6-Dioxo-8-phenyl-1,2,3,6-tetrahydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl esterHCID 67067863—
Reactant7-Amino-8-hydroxy-3-iodo-2-phenyl-chromen-4-oneHCID 67067919—
Product7-Iodo-8-phenyl-3H-chromeno[7,8-d]oxazole-2,6-dioneHCID 67067819100%

Reaction Steps

Following the procedure used to {1-[4-(2,6-dioxo-8-phenyl-1,2,3,6-tetrahydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 7-amino-8-hydroxy-3-iodo-2-phenyl-chromen-4-one was reacted to give the title compound as a yellow solid (105 mg, 100%). LCMS (Method G): RT=3.27, [M+H]+=406.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08546376B2
Source datasetuspto-grants-2013_10
ORD IDord-76c6c2f8e389484cbc5eef06a297cb7a
Source noteuspto-grants-2013_10