3-[4-(1-Amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one → 7-[4-(1-Amino-cyclobutyl)-phenyl]-8-phenyl-3H-chromeno[7,8-d]oxazole-2,6-dione

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one, {1-[4-(2,6-dioxo-8-phenyl-3,6-dihydro-2H-chromeno[7,8-d]oxazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (31 mg, 58%). 1H NMR (400 MHz, DMSO-d6): δ 7.64 (d, J=8.2 Hz, 1H), 7.43-7.38 (m, 5H), 7.37-7.31 (m, 2H), 7.26-7.22 (m, 2H), 7.02 (d, J=8.2 Hz, 1H), 2.58-2.49 (m, 2H), 2.42-2.32 (m, 2H), 2.16-2.05 (m, 1H), 1.82-1.71 (m, 1H). LCMS (Method E): RT=3.08 min, [M+H]+=425.

Provenance & Evidence