3-[4-(1-Amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one → 7-[4-(1-Amino-cyclobutyl)-phenyl]-6-phenyl-1H-4,5-dioxa-1-aza-phenanthrene-2,8-dione

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one, {1-[4-(2,8-dioxo-6-phenyl-1,2,3,8-tetrahydro-4,5-dioxa-1-aza-phenanthren-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (31 mg, 58%). 1H NMR (400 MHz, DMSO-d6): δ 7.69 (d, J=8.8 Hz, 1H), 7.42-7.30 (m, 7H), 7.12-7.09 (m, 2H), 7.04 (d, J=8.8 Hz, 1H), 4.80 (s, 2H), 2.39-2.31 (m, 2H), 2.10-2.01 (m, 2H), 2.01-1.93 (m, 1H), 1.69-1.57 (m, 1H). LCMS (Method E): RT=3.03 min, [M+H]+=439.

Provenance & Evidence