HRID1037379

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(F)cc4c3=O)cc2)CCC1

HCID67067635

未命名化合物

HCID67068012

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4c(O)c(N)ccc4c3=O)cc2)CCC1

HCID67067987

未命名化合物

收率 14%

PROCEDURE

实验过程

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 7-iodo-8-phenyl-chromeno[7,8-d]oxazol-6-one was reacted to give the title compound as a yellow oil (25 mg, 14%). LCMS (Method G): RT=3.75 min, [M+H]+=499.

WORKUP

后处理

customwas reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-498860300a434d94a046846145d98693
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546376B2
来源说明: uspto-grants-2013_10

反应 SMILES

[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15](C3C(=O)C4C(=CC=C(F)C=4)OC=3C3C=CC=CC=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].I[C:38]1[C:43](=[O:44])[C:42]2[CH:45]=[CH:46][C:47]3[N:48]=C[O:50][C:51]=3[C:41]=2[O:40][C:39]=1[C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1>>[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:13]=[CH:14][C:15]([C:38]3[C:43](=[O:44])[C:42]4[C:41](=[C:51]([OH:50])[C:47]([NH2:48])=[CH:46][CH:45]=4)[O:40][C:39]=3[C:52]3[CH:53]=[CH:54][CH:55]=[CH:56][CH:57]=3)=[CH:16][CH:17]=2)[CH2:9][CH2:10][CH2:11]1)([CH3:4])([CH3:2])[CH3:3]