3-[4-(1-Amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one → HCID 178507114, compound

Participants

Reaction Steps

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one, {1-[4-(6-oxo-8-phenyl-2-trifluoromethyl-1,6-dihydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a yellow solid (25 mg, 80%). 1H NMR (400 MHz, DMSO-d6): δ 7.65 (d, J=9.0 Hz, 1H), 7.56 (d, J=9.0 Hz, 1H), 7.50-7.47 (m, 2H), 7.45-7.31 (m, 7H), 2.65-2.56 (m, 2H), 2.53-2.44 (m, 2H), 2.21-2.09 (m, 1H), 1.88-1.76 (m, 1H). LCMS (Method E): RT=3.43 min, [M+H]+=476.

Provenance & Evidence