反应详情

Following the procedure used to prepare 3-[4-(1-amino-cyclobutyl)-phenyl]-2-phenyl-7H-pyrano[2,3-e]indazol-4-one, {1-[4-(1-methyl-6-oxo-8-phenyl-1,6-dihydro-chromeno[7,8-d]imidazol-7-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester was reacted to give the title compound as a white solid (43 mg, 85%). 1H NMR (400 MHz, DMSO-d6): δ 8.44 (s, 1H), 7.88 (d, J=9.2 Hz, 1H), 7.73 (d, J=9.2 Hz, 1H), 7.54-7.50 (m, 2H), 7.44-7.34 (m, 5H), 7.18-7.13 (m, 2H), 4.21 (s, 3H), 2.42-2.34 (m, 2H), 2.12-2.04 (m, 2H), 2.04-1.94 (m, 1H), 1.70-1.59 (m, 1H). LCMS (Method E): RT=2.86 min, [M+H]+=422.

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