tert-Butyl (1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutyl)carbamate → {1-[4-(2,8-Dioxo-6-phenyl-1,2,3,8-tetrahydro-4,5-dioxa-1-aza-phenanthren-7-yl)-phenyl]cyclobutyl}-carbamic acid tert-butyl ester

Participants

Reaction Steps

Following the procedure used to prepare tert-butyl (1-(4-(1-(cyanomethyl)-6-oxo-8-phenyl-1,6-dihydropyrano[3,2-g]indazol-7-yl)phenyl)cyclobutyl)carbamate reacted 8-iodo-9-phenylchromeno[8,7-b][1,4]oxazine-3,7(2H,4H)-dione (150 mg, 0.358 mmol), tert-butyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutylcarbamate (170 mg, 0.455 mmol) was reacted to give the title compound (100 mg, 52%). LCMS (Method I): RT=6.87 min, [M+H]+=539.

Provenance & Evidence