HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Methylsulfonyl)phenylboronic Acid → tert-butyl (1-(4-(8-(2-(methylsulfonyl)phenyl)-4-oxo-2-phenyl-4H-pyrano[2,3-c]pyridin-3-yl)phenyl)cyclobutyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Methylsulfonyl)phenylboronic Acid | HCID 2773539 | — |
| Reactant | 3-(4-(1-aminocyclobutyl)phenyl)-8-(1-isobutyl-1H-pyrazol-4-yl)-2-phenyl-4H-pyrano[2,3-c]pyridin-4-one | HCID 67067767 | — |
| Reactant | tert-Butyl 1-(4-(8-chloro-4-oxo-2-phenyl-4H-pyrano[2,3-c]pyridin-3-yl)phenyl)cyclobutylcarbamate | HCID 86671031 | — |
| Product | tert-butyl (1-(4-(8-(2-(methylsulfonyl)phenyl)-4-oxo-2-phenyl-4H-pyrano[2,3-c]pyridin-3-yl)phenyl)cyclobutyl)carbamate | HCID 67067938 | 62% |
Reaction Steps
Following the procedure used to prepare 3-(4-(1-aminocyclobutyl)phenyl)-8-(1-isobutyl-1H-pyrazol-4-yl)-2-phenyl-4H-pyrano[2,3-c]pyridin-4-one, tert-butyl (1-(4-(8-chloro-4-oxo-2-phenyl-4H-pyrano[2,3-c]pyridin-3-yl)phenyl)cyclobutyl)carbamate was reacted with (2-(methylsulfonyl)phenyl)boronic acid to give the title compound (40 mg, 62%). LCMS (Method I): RT=7.31 min, [M+2]+=567 (-tBu).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546376B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-608ed4134a6a422f9f0ff3f2025ed324 |
| Source note | uspto-grants-2013_10 |