Hydrazine → HCID 178512582, compound

HRID 1037479Notes

Reaction equation

HRID 1037479 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:3]=1[C:4](=S)[NH2:5].[NH2:12][NH2:13]>CCO>[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:3]=1[C:4](=[NH:5])[NH:12][NH2:13]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 227131172,5-Difluorothiobenzamide

Product 1

HCID 178512582HCID 178512582, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of 2,5-difluorobenzothioamide (22.5 g, 129.7 mmol) in EtOH (150 mL) was added hydrazine (6.1 mL, 194.5 mmol). After stirring at room temperature for 30 min, reaction was complete by LC/MS and white solid precipitated. The precipitate was filtered and washed with Hexanes to afford 2,5-difluorobenzimidohydrazide (5.52 g, 94%).

Workup

  1. customreaction
  2. customprecipitated
  3. filtrationThe precipitate was filtered
  4. washwashed with Hexanes

Sources & evidence

ORD record
ord-1223a1951588459db1247228da842eca
Source dataset
uspto-grants-2013_10
Patent number
US08546434B2

Reaction notes

Loading…