反应详情

To a solution of 9-(2-hydroxy ethyl)carbazole (1.65 g, 7.81 mmol) in 2-chloro-2-methylpropane (25.0 ml) was added aluminum trichloride (0.54 g, 4.05 mmol) at room temperature under nitrogen atmosphere and stirring. After 1 minute, the addition of AlCl3, insoluble 9-(2-hydroxyethyl)carbazole disappeared. The reaction was carried out at room temperature for 25 minutes, and water (20.0 ml) was added. The product was extracted with ethyl acetate (3×20.0 ml). The organic layer was washed with water (3×60.0 ml), and then ethyl acetate was evaporated under vacuum. The product was applied to a silica gel column [ethyl acetate/hexanes (3.5:6.5)] to yield 2.1 g (84.0%) of a white solid after recrystallization from dichloromethane/hexanes.

1. waitThe reaction was carried out at room temperature for 25 minutes
2. extractionThe product was extracted with ethyl acetate (3×20.0 ml)
3. washThe organic layer was washed with water (3×60.0 ml)
4. customethyl acetate was evaporated under vacuum