反应详情

温度

90 °C

To a stirred suspension of compound (vi) (3.3 g, 8.6 mmol) in ethanol (35 mL) was added aqueous NaOH (3.44 g, 86 mmol) and the reaction mixture was heated to 90° C. and maintained for 15 h when TLC and LCMS showed the absence of SM and formation of product. Concentration of the solvent gave a crude residue which was dissolved in water and filtered. The filtrate was acidified with dilute HCl at which time the product precipitated and was filtered to give the crude product which was purified by acid-base treatment to give 2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carboxylic acid (vii) (2.2 g, 63%).

1. temperaturemaintained for 15 h when TLC and LCMS
2. customConcentration of the solvent gave a crude residue which
3. filtrationfiltered
4. customprecipitated
5. filtrationwas filtered
6. customto give the crude product which
7. customwas purified by acid-base treatment