Dichloromethane → HCID 67776540, compound

Participants

Reaction Steps

A degassed suspension of 5-bromo-2-[6-(4-fluorophenoxy)pyridin-3-yl]-N-methyl-6-nitro-2H-indazole-3-carboxamide (10 mg, 0.021 mmol), potassium phosphate (35 mg, 0.16 mmol), potassium cyclopropyltrifluoroborate (19 mg, 0.13 mmol) and Pd(dppf)Cl2.CH2Cl2 (3 mg, 0.004 mmol) in toluene (1 mL) and water (0.1 mL) was heated under microwave irradiation at 110° C. for 1 h. The reaction mixture was diluted with EtOAc (3 mL), washed with water (1 mL) and brine (1 mL), then dried (MgSO4) and concentrated to dryness. The residue was purified by flash column chromatography eluting with MeOH/DCM (0-10%) to give 5-cyclopropyl-2-[6-(4-fluorophenoxy)pyridin-3-yl]-N-methyl-6-nitro-2H-indazole-3-carboxamide as a tan solid (7 mg, 73%).

Provenance & Evidence