Trifluoroacetic acid → HCID 56962531, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 3-{[2-(4-bromophenyl)-5-cyclopropyl-3-(methylcarbamoyl)-2H-indazol-6-yl](methylsulfonyl)amino}pyrrolidine-1-carboxylate (12 mg, 0.019 mmol) in DCM (0.5 mL) was added trifluoroacetic acid (50 μL) and the mixture was stirred at 40° C. for 40 min. The mixture was cooled to RT, washed with saturated aqueous sodium bicarbonate (0.5 mL), dried (MgSO4) and concentrated to dryness. The residue was purified by preparative LCMS (5-100% ACN in 0.1% aqueous formic acid) to afford 2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-[(methylsulfonyl)(pyrrolidin-3-yl)amino]-2H-indazole-3-carboxamide as a white solid (4.4 mg, 44%).

Provenance & Evidence