HRID1037549

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9731

4-Fluoroaniline

C6H6FN

结构：CNC(=O)c1c2cc(C3CC3)c(N(CCCO)S(C)(=O)=O)cc2nn1-c1ccc(Br)cc1

HCID56962769

未命名化合物

结构：CNC(=O)c1c2cc(C3CC3)c(N(CCCO)S(C)(=O)=O)cc2nn1-c1ccc(Nc2ccccc2F)cc1

HCID56962770

未命名化合物

PRODUCTS

生成物

结构：CNC(=O)c1c2cc(C3CC3)c(N(CCCO)S(C)(=O)=O)cc2nn1-c1ccc(Nc2ccc(F)cc2)cc1

HCID67517791

未命名化合物

PROCEDURE

实验过程

5-Cyclopropyl-2-{4-[(4-fluorophenyl)amino]phenyl}-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-N-methyl-2H-indazole-3-carboxamide (ii) was prepared similarly to Compound (5) (Method C, Step b) from 2-(4-bromophenyl)-5-cyclopropyl-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-N-methyl-2H-indazole-3-carboxamide (i) using 4-fluoroaniline instead of 2-fluoroaniline.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c43dfc94bd3c4e7d9d2281cdc914ba96
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546389B2
来源说明: uspto-grants-2013_10

反应 SMILES

[CH:1]1([C:4]2[C:12]([N:13]([CH2:18][CH2:19][CH2:20][OH:21])[S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][C:10]3[C:6](=[C:7]([C:36]([NH:38][CH3:39])=[O:37])[N:8]([C:22]4[CH:27]=[CH:26][C:25]([NH:28]C5C=CC=CC=5F)=[CH:24][CH:23]=4)[N:9]=3)[CH:5]=2)[CH2:3][CH2:2]1.BrC1C=CC(N2C(C(NC)=O)=C3C(C=C(N(CCCO)S(C)(=O)=O)C(C4CC4)=C3)=N2)=CC=1.[F:72][C:73]1[CH:79]=[CH:78][C:76](N)=[CH:75][CH:74]=1>>[CH:1]1([C:4]2[C:12]([N:13]([CH2:18][CH2:19][CH2:20][OH:21])[S:14]([CH3:17])(=[O:15])=[O:16])=[CH:11][C:10]3[C:6](=[C:7]([C:36]([NH:38][CH3:39])=[O:37])[N:8]([C:22]4[CH:23]=[CH:24][C:25]([NH:28][C:76]5[CH:78]=[CH:79][C:73]([F:72])=[CH:74][CH:75]=5)=[CH:26][CH:27]=4)[N:9]=3)[CH:5]=2)[CH2:3][CH2:2]1