HRID1037551

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CNC(=O)c1c2cc(C3CC3)c(N(CCN)S(C)(=O)=O)cc2nn1-c1ccc(Br)cc1

HCID56962772

未命名化合物

结构：CNC(=O)c1c2cc(C3CC3)c(N(CCCN3C(=O)c4ccccc4C3=O)S(C)(=O)=O)cc2nn1-c1ccc(Nc2ccc(F)cc2)cc1

HCID69248953

未命名化合物

PRODUCTS

生成物

结构：CNC(=O)c1c2cc(C3CC3)c(N(CCCN)S(C)(=O)=O)cc2nn1-c1ccc(Nc2ccc(F)cc2)cc1

HCID67513022

未命名化合物

PROCEDURE

实验过程

6-[3-Aminopropyl(methylsulfonyl)amino]-5-cyclopropyl-2-[4-(4-fluoroanilino)phenyl]-N-methyl-indazole-3-carboxamide (iv) was prepared by hydrolysis of compound (iii) using a similar procedure to Compound (7) (Method D, Step b).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c2e5f3c6463c4fd98899848e7e4b0ded
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546389B2
来源说明: uspto-grants-2013_10

反应 SMILES

[CH:1]1([C:4]2[C:12]([N:13]([CH2:18][CH2:19][CH2:20][N:21]3C(=O)C4C(=CC=CC=4)C3=O)[S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][C:10]3[C:6](=[C:7]([C:46]([NH:48][CH3:49])=[O:47])[N:8]([C:32]4[CH:37]=[CH:36][C:35]([NH:38][C:39]5[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=5)=[CH:34][CH:33]=4)[N:9]=3)[CH:5]=2)[CH2:3][CH2:2]1.NCCN(S(C)(=O)=O)C1C(C2CC2)=CC2C(C=1)=NN(C1C=CC(Br)=CC=1)C=2C(NC)=O>>[NH2:21][CH2:20][CH2:19][CH2:18][N:13]([S:14]([CH3:17])(=[O:15])=[O:16])[C:12]1[C:4]([CH:1]2[CH2:3][CH2:2]2)=[CH:5][C:6]2[C:10]([CH:11]=1)=[N:9][N:8]([C:32]1[CH:33]=[CH:34][C:35]([NH:38][C:39]3[CH:44]=[CH:43][C:42]([F:45])=[CH:41][CH:40]=3)=[CH:36][CH:37]=1)[C:7]=2[C:46]([NH:48][CH3:49])=[O:47]