Dimethylformamide → HCID 56962849, compound

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Reaction Steps

NB: 5-Cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-2H-indazole-3-carboxamide (14) was prepared following the procedure described in Method F using 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-2H-indazole-3-carboxamide (13) in place of 2-(4-fluorophenyl)-5-methoxy-N-methyl-6-[(methylsulfonyl)amino]-2H-indazole-3-carboxamide (10). 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-2H-indazole-3-carboxamide (13) in turn was prepared according to Method A using 4-fluoroaniline in place of 4-bromoaniline in Step d. Alternatively, esterification may be carried out as for Compound (116) with a suitable carboxylic acid using a coupling agent (e.g. DCC), 4-DMAP in DMF.

Provenance & Evidence