反应详情

温度

70 °C

To a stirred suspension of compound (xiv) (50 mg, 0.16 mmol) in ethanol:water (1:1, 6 mL) was added sodium hydroxide (63 mg, 0.16 mmol) and the reaction mixture was heated at 70° C. for 2 h. The reaction mixture was cooled to RT and the volatiles were removed under reduced pressure. The residue was acidified to pH 2 upon addition of 2N hydrochloric acid. The resulting precipitate was filtered, washed with water (2×20 mL) and dried (Na2SO4) to give 6-bromo-2-(4-fluorophenyl)-2H-indazole-3-carboxamide (xv) (50 mg, 94%) as white solid. ESI-MS m/z calculated for [M+H]+: 334.00; found: 334.00.

1. temperatureThe reaction mixture was cooled to RT
2. customthe volatiles were removed under reduced pressure
3. additionThe residue was acidified to pH 2 upon addition of 2N hydrochloric acid
4. filtrationThe resulting precipitate was filtered
5. washwashed with water (2×20 mL)
6. dry with materialdried (Na2SO4)