Potassium trimethylsilanolate → HCID 59267979, compound

Participants

Reaction Steps

To a solution of 2-(azetidine-1-sulfonyl)-2-methyl-propionic acid ethyl ester (5.0 g, 21 mmol) in tetrahydrofuran (200 mL) at room temperature is added potassium trimethylsilanolate (8.2 g, 64 mmol). The reaction is stirred for 1 h. After this time, the mixture is diluted with a solution of 1N aqueous hydrochloric acid (50 mL) and extracted with dichloromethane (250 mL). The organic phase is dried (MgSO4), filtered and concentrated under reduced pressure to provide the title compound as a white solid, m/z 208 [M+H+].

Provenance & Evidence