HCID 58238620, compound → HCID 136177201, compound

Participants

Reaction Steps

Compound 6 (1.1 g, 2.1 mmol, 1.0 equiv) was dissolved in ethanol (60 mL) and 10% palladium (50% aqueous) on carbon (0.3 g) was added. The material was shaken on a Parr hydrogenator under a hydrogen atmosphere (30 psi) for 24 hr. The reaction was filtered through a layer of Celite and rinsed with dichloromethane (100 mL). The product was absorbed onto silica gel (3 g) by concentration under reduced pressure. This material was purified on a silica gel column (20 g) by eluting with ethyl acetate (2%) in heptanes (600 mL). The desired product was isolated pure in 45% yield (0.39 g).

Provenance & Evidence